If retention times have shortened over a quick period of time, this article explains why it might have caused it and some steps to take to fix it.
My Retention Times Shortened Over the Course of one Month With a new Column
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Peak Articles
A large Negative Peak Before Nitrite is Interfering With the Nitrite Peak With Biological Samples, What Causes This?
The potential causes and resolution to a large negative peak before the nitrite peak in biological samples are outlined in this article. The negative peak can arise either from the column, autosampler settings, or sample overloading.
ENO-20/30 Shortened Retention Times for Tissue or Blood Samples Issue
This article outlines ways to improve the retention time for tissue or blood samples by either lowering concentration or changing sample preparation.
Issue with ENO-20/30 Peaks (Small Peak, Less Signal, Weak Signal) with Nitrate and Nitrite Standards
This article outlines some procedures to improve the peak signal and shape by observing chromatograms, changing hardware parameters, and cleaning the unit.
I have Broad Peaks When Using a Manual Injector
This article outlines a procedure to solve broad peaks when injecting samples with a manual injector.
I Observe a Large Ghost Peak Before my GABA Peak
This article outlines a resolution to a large ghost peak before a GABA peak.
Absence of Peaks When Using HTEC
List of quick potential issues and fixes for when you do not observe peaks in your chromatogram.
I Have Split/Broad Peaks and Shorter Retention Times for PP-ODS Columns
The recommended way to wash a PP-ODS column when a simple water/methanol wash does not fix the peak issue is outlined in this article.
Why are the Tops of my Peaks Cut Off?
This outlines a quick solution to fixing the tops of peaks being cut off in a chromatogram.
Drop in Peak Height – Causes and Resolutions
This article explains some common causes for drops in peak height as well as common and simple solutions to the issue